Run in groups or tell a loved one
Because runners are fit super elite athletes we often think we're invincible - even the guys. Wrong!!! Too much can go wrong while running alone. Runners have been abducted, robbed, shot, and unfortunately killed. If at all possible find a running buddy or group to run with. If you must run alone tell a loved one or friend where you're running and how long you will be out.
Bright light, Bright Light

Say what, you're listening to the Backstreet Boys?
Technology is great... MP3 players, iPhones, and cell phones have the ability to carry your entire Beatles collection and play the songs randomly while you bounce beautifully down the road. Unfortunately, while you're bopping your head you can't hear traffic, car horns, or that strange guy running up behind you. If you want to enjoy your playlist do it on a treadmill. When you're on the road you need to be aware of your surroundings. But, if you just can't get away from the tunes then leave one ear bud out.
Secret agent man
According to Road ID, each year 122,000 runners, walkers, and cyclists are hit by cars. To me its not an option, you must carry or wear some form of ID which lets folks know who you are in case of an emergency. Also, unless you have a shoe phone or Dick Tracey spy watch, do yourself a favor and carry a phone.

Always run against traffic. This allows you to see cars coming and they can easily see you. Follow all pedestrian laws, looking both ways before crossing. Even if you're right don't be on the wrong side of a car's bumper. Neighborhoods are the worse, be especially careful of cars on the streets and opening doors. Also be on the look out for cars coming out of the driveway. Most homeowners aren't expecting to see a runner as they back out.
So, you're fit and can run a ton of miles
Don't take this the wrong way, but so what. What are you going to do after running 4 miles and someone attacks you (see run in groups). Even though we like to think all that work in the gym and running miles will allow you to protect yourself it won't. Ladies and GENTs, take a class on self defense. The life you save may be your own.
Keep Running!!
Rome